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Chemotherapy-induced peripheral neuropathy is nerve damage caused by certain chemotherapy drugs. It typically appears as tingling, burning, numbness, or weakness — most often beginning in the hands and feet — and can persist after treatment ends.

The course of CIPN varies. Some people experience partial or substantial improvement after treatment, while symptoms persist for others. Discuss new, changing, or persistent symptoms with your healthcare team.

Tingling, burning, and numbness reflect disrupted nerve signaling. Damage to myelin (the insulation around nerves), to nerve cell membranes, or to the mitochondria that fuel nerve cells can all distort the signals nerves send to the brain.

Myelin is the fatty insulating sheath that wraps peripheral nerves and lets them transmit signals quickly and clearly. Healthy myelin is essential for normal sensation, movement, and coordination.

Fatty acids are components of cell membranes, including lipid-rich myelin. Novilora contains a defined profile of specific fatty acids selected for their biological relevance to nerve health.

Palmitoylethanolamide (PEA) is a fatty acid amide produced naturally by the body, especially in response to stress or injury. PEA has been studied for its role in supporting healthy inflammatory balance and nerve cell function.

The prospective, multicenter, single-arm observational STEFANO study evaluated OnLife® in 146 analyzed patients with established CIPN across 21 oncology centers over three months. The strongest signal was observed in the paclitaxel cohort. Physician-assessed improvement or stabilization, patient-reported outcomes, and quality-of-life outcomes were measured separately. The study was not randomized or placebo-controlled.

There is no single recovery timeline. The course depends on the chemotherapy involved, the extent of nerve injury, and individual health factors. The STEFANO observational study evaluated OnLife® over three months, but that period does not predict an individual's course.

Chemotherapy is the focus of CIPN by definition, but peripheral neuropathy can also arise from many other causes (diabetes, vitamin deficiencies, autoimmune conditions). The science Novilora is built on focuses specifically on the CIPN context.

Cold can amplify sensitivity in nerves that are already compromised. Warming the extremities is a simple, well-tolerated comfort measure for many people with CIPN.

Novilora is a dietary supplement, not a medication. It is intended to support nerve health and is not intended to diagnose, treat, cure, or prevent any disease.

Individual outcomes vary, and no supplement guarantees improvement. Track symptoms and functional changes over time and discuss them with your healthcare provider.