Where the evidence is strongest
Exercise, sleep, nutrition, and symptom-management strategies may support general health during survivorship. Recommendations should be individualized with a healthcare professional.
Emerging formulations
The OnLife® fatty acid + PEA formulation was evaluated in the prospective, multicenter, single-arm observational STEFANO study of 146 analyzed patients with established CIPN over three months. Physician-assessed and patient-reported outcomes were evaluated separately.
How to think about evidence
STEFANO was not randomized or placebo-controlled. It cannot establish how much observed improvement was attributable to OnLife® versus treatment-independent recovery after chemotherapy. The authors called for prospective randomized multicenter research to further confirm benefit.